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cruelshoes Joined: 23 Sep 2005 Posts: 2550 Location: Washington State	Posted: Thu Aug 07, 2008 9:03 am    Post subject: Celaic Disease vs. NCGS - By Dr. Fasano A link to an interesting little interview with Dr. Fasano about celiac vs. Non-Celiac Gluten Sensitivity http://www.diet.com/dietblogs/read_blog.php?title=Celiac+Disease+vs.+Gluten+Sensitivity&blid=11838 I found this description of the innate vs. adaptive immune systems to be particularly interesting Quote: In an article you wrote about Digestive Disease Week for Medscape Gastroenterology you state that gluten sensitivity "may be related to activation of the innate immune system without the involvement of the adaptive immune system." Can you please explain further, including what is meant by innate immune system and adaptive immune system? The innate immune system is the most ancestral form of defense we have against "invaders," while the adaptive immune system is a more recent branch of our immune system. Once our body comes in contact with a substance from the environment that may represent a signal of danger, the innate immune system reacts immediately to try to eliminate the "attacker." At the same time, the adaptive immune system will intervene with a more sophisticated, long process, during which the attacker is studied, its conformation evaluated, and a "customized response" to that particular molecule is engineered (i.e. specific antibodies). Further, the adaptive immune system will save this information as immune response memory, so that at the next encounter there is no need to re-do the job. In autoimmune diseases, like celiac disease, there is a coordinate response between innate and adaptive immune system, a response that ends up in the wrong direction (i.e.; attacking its own body rather than the "invader"). In gluten sensitivity, there is only an innate immune response, since the adaptive immune system seems not involved. _________________ -Colleen Dx 8/05 via bloodwork/biopsy 10-YO son Dx 11/05 via bloodwork/biopsy Daughters (12 and 2) have neg. bloodwork A woman is like a tea bag-you never know how strong she is until she gets in hot water. - Eleanor Roosevelt
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