Single most imporant question regarding celiac disease

KansasCowboy · Joined: 13 May 2008 Posts: 2

Hi,

I have the opportunity to speak with the Director for The Center for Celiac Research, West early next week and wanted to know your most important question regarding celiac disease.

I'll either transcribe or post an .mp3 of the interview for everyone afterwards.

-KC

aklap · Joined: 02 Oct 2004 Posts: 8607 Location: WI, USA

Hey GlutenGuy,

Cool! You must be pretty busy, is this part of your paper you're doing? I'd love to hear the interview via an mp3.

Is there any particular facet of CD you'd like us to cover?

Hmmm what question to Michelle Pietzak, MD would I like answered....
_________________
Al

“We cannot all do great things, but we can do small things with great love.” Mother Teresa

wildbill · Joined: 15 Apr 2008 Posts: 15 Location: Prior Lake, MN

I'd like to know in layman's terms how the antibody kills the villia in our intestines.

Fifi · Joined: 01 Feb 2008 Posts: 230 Location: Wauconda, IL

I'd like to know how this suddenly after 48 years of life become such a huge issue.

nancw · Joined: 04 Oct 2006 Posts: 855 Location: Denver, CO

Is this truly a spectrum disease w/ GI on one end and CD on the other, and why isn't positive dietary response accepted as enough for a dx?

Oh, that's TWO questions. Wink

_________________
Nance

gluten, dairy, soy, rice, yeast and 99% grain-free

wildbill · Joined: 15 Apr 2008 Posts: 15 Location: Prior Lake, MN

Hopefully this is OK to post here.

I was reading wiki again and answered my question with a bit more information too from http://en.wikipedia.org/wiki/Celiac_disease

The explaination in the 2nd paragraph wasn't quite enough for a infomaniac like me:

Upon exposure to gliadin, the enzyme tissue transglutaminase modifies the protein, and the immune system cross-reacts with the bowel tissue, causing an inflammatory reaction. That leads to flattening of the lining of the small intestine, which interferes with the absorption of nutrients.

The explaination much farther down works for me with the 2nd part added info.:

Villous atrophy and malabsorption

The inflammatory process, mediated by T cells, leads to disruption of the structure and function of the small bowel's mucosal lining, and causes malabsorption as it impairs the body's ability to absorb nutrients, minerals and fat-soluble vitamins A, D, E and K from food. Lactose intolerance may be present due to the decreased bowel surface and reduced production of lactase but typically resolves once the condition is treated.

Alternative causes of this tissue damage have been proposed and involve release of interleukin 15 and activation of the innate immune system by a shorter gluten peptide (p31–43/49). This would trigger killing of enterocytes by lymphocytes in the epithelium.[1] The villous atrophy seen on biopsy may also be due to unrelated causes, such as tropical sprue, giardiasis and radiation enteritis. While positive serology and typical biopsy are highly suggestive of coeliac disease, lack of response to diet may require these alternative diagnoses to be considered.[6]

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KansasCowboy · Joined: 13 May 2008 Posts: 2

I've begun to post some of the answers I've gotten for your questions. I have a lot of material in the form of .mp3s, videos, etc. that will be posted up on the blog over the next few weeks: www.gluten-answers.com/blog/

I hope this helps some of you,

- KC

windinthetrees · Joined: 28 Jul 2008 Posts: 72

what is the difference between celiac disease and gluten intolerance/ don't they both do the same to the intestine?

cruelshoes · Joined: 23 Sep 2005 Posts: 2550 Location: Washington State

baldridgem · Joined: 11 May 2005 Posts: 79

What about Gluten Sensitivity and Celiac Disease?
I am gluten sensitive ( Entero Lab) and I have gluten induced small intestinal malasorption/ damage. Is'nt that celiac disease? Or is malasorption/damage and villi damage different?

cruelshoes · Joined: 23 Sep 2005 Posts: 2550 Location: Washington State